RAF Typhoon jets have joined forces with France's air force in a combined operation on an hidden munitions depot in Syrian territory employed by the IS group, as stated by the UK's MoD.
The site, pinpointed through intelligence, was assessed as containing munitions and bombs, the statement said, and was positioned in hills just north of the ancient city of Palmyra in central Syria.
"The RAF jets employed Paveway IV guided bombs to target a several approach shafts down to the facility... initial indications are that the objective was successfully hit," the ministry announced.
There was no evidence of any harm to civilians in the strike on Saturday evening and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as Daesh - imposed jihadist rule over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This operation demonstrates British leadership, and resolve to operate in unison with our allies, to stamp out any re-emergence of Daesh and their violent and radical beliefs in the area," Britain's Defence Chief John Healey remarked.
RAF aircraft have conducted patrols over Syria to "prevent any efforts to regroup" of IS after its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I extend gratitude to all the members of British forces participating in this strike for their professionalism and their bravery," Healey said. "They were among thousands of British personnel stationed over Christmas and New Year. This mission, to take out militants who threaten our way of life, demonstrates how our armed forces are ready to step up, continuously, keeping Britain secure within its borders and powerful internationally."
During December, the American forces conducted what it described as a "major assault" targeting IS targets in the country, after an ambush claimed the lives of two US servicemembers and a local interpreter in Palmyra.
The United Nations estimates IS still boasts an estimated 5,000 to 7,000 fighters in both countries.